Analysis of p.(Val839Ala) variant, VLGR1 gene, vlgr1 protein (6306 residues)
Ortholog conservation: |
Number of sequences | AAPI* | AAPIR** | Number of divergencies | Number of mutant | Number of gaps | Conservation of V839 | Conservation - gap |
---|---|---|---|---|---|---|---|
20 | 65.35% | 75.44% | 5 details |
0 details |
0 details |
15 / 20 (75.00%) | 15 / 20 (75.00%) |
*AAPI: Alignment Average Percentage Identity
**AAPIR: Alignment Average Percentage Identity of the Region (20 residues surrounding position 839). AAPIR appears in green if it is more than 10% compared to AAPI, in red if less than 10%.
You can check the AAPIRs compared with AAPI of the whole alignment by clicking here. The help page will tell you more.
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Display region alignment (21 residues, Fasta format)
Domain conservation: |
The residue belongs to the domain Calx-beta 6.
821 |
| 861 |
|
|||
There are no alignments available concerning the domain Calx-beta of the protein vlgr1 or the residue is not present in the alignment.
Secondary structure analysis: |
Residu V839 is predicted to belong to a β strand. Probability is 0.987.
Direct environment is as follow:
E | R | E | I | V839 | I | T | L | L |
Observed frequencies in β strands:
V: 1.8
A: 0.79
Mutant residu is less observed in this type of structure.
3D analysis: |
Models provided and analysed by USMA must be considered as predictions, therefore be careful when interpreting the results. All efforts have been made to build structures of quality, however, they are provided with NO WARRANTY as to their accuracy with the real biological molecules studied.
Predicted wild type and mutant structures have been compared. You will find the results below. Please note that USMA's "3D engine" is unable to analyse interactions with non amino-acids molecules (e.g. ATP or Ca2+).
PDB template | Sequence identity* | Molprobity bad rotamers | Molprobity Ramachandran outliers | Molprobity Ramachandran favored |
---|---|---|---|---|
3GIN | 31.4 % | 0/77 - 0 % | 2/84 - 2.4 % | 77/84 - 91.7 % |
* between target and template
Otherwise, see detailed Molprobity output
V839 | A839 |
---|---|
none | none |
V839 | A839 |
---|---|
none | none |
V839 (wild-type) | A839 (mutant) |
---|---|
JSmol Legends: The residue at the position 839 is located in the center, labelled in yellow and surrounded by its neighboring residues (distance < 5 Å). Amino acids involved in H-bonds with the residue 839 are labelled in blue. Amino acids involved in steric clashes with the residue 839 are labelled in red.
Additional ressources: |
See accession numbers of sequences used or references.
Execution time: 1 wallclock secs ( 0.16 usr 0.01 sys + 0.81 cusr 0.35 csys = 1.33 CPU)