| Ortholog conservation: |
 |
| Number of sequences |
AAPI* |
AAPIR** |
Number of divergencies |
Number of mutant |
Number of gaps |
Conservation of G64 |
Conservation - gap |
| 30 |
75.50% |
81.77% |
0
details |
0
details |
0
details |
30 / 30 (100.00%) |
30 / 30 (100.00%) |
The alignment does not show any divergent sequences.
The mutant residue cannot be found in the alignment.
There is no gap in the alignment.
*AAPI: Alignment Average Percentage Identity
**AAPIR: Alignment Average Percentage Identity of the Region (20 residues surrounding position 64). AAPIR appears in green if it is more than 10% compared to AAPI, in red if less than 10%.
You can check the AAPIRs compared with AAPI of the whole alignment by clicking here.
The help page will tell you more.
Informativity of this alignment: P0 = 0.0079, with an average substitution per position of 4.83.
This means that you have a probability of 0.9921 (99.21%) that position 64 is invariant because it is functionally constrained.
More information here.
Display alignment
Click on the alignment to zoom in and out.
| | | | | | | | | | | | | | | | | | | | | | | | | | | | 64 | | | | | | | | | | | | | | | | | | | | | | | | | | |
| Homo sapiens | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Pan troglodytes | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Pongo pygmaeus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Gorilla gorilla | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Macaca mulatta | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Otolemur garnettii | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
R |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
T |
F |
F |
P |
D |
L |
| Microcebus murinus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
- |
F |
P |
D |
L |
| Rattus norvegicus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Mus musculus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
K |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Canis familiaris | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
I |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
L |
F |
P |
D |
L |
| Felis catus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
L |
F |
P |
D |
L |
| Equus caballus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
A |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
Q |
F |
S |
F |
F |
P |
D |
L |
| Pteropus vampyrus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Cavia porcellus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Bos taurus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
K |
R |
P |
F |
R |
F |
S |
F |
F |
L |
D |
L |
| Erinaceus europaeus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
E |
L |
| Tursiops truncatus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Vicugna pacos | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
I |
S |
F |
F |
P |
D |
L |
| Oryctolagus cuniculus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
D |
K |
F |
M |
G |
E |
M |
H |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Dipodomys ordii | C |
T |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
P |
E |
L |
D |
K |
F |
T |
G |
E |
V |
H |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Monodelphis domestica | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
E |
K |
F |
T |
G |
E |
I |
Q |
Y |
G |
L |
F |
H |
G |
E |
G |
V |
R |
Q |
C |
G |
L |
G |
A |
R |
P |
F |
R |
F |
S |
F |
F |
P |
D |
L |
| Ornithorhynchus anatinus | C |
Q |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
Q |
E |
L |
E |
K |
F |
I |
G |
E |
I |
Q |
Y |
G |
L |
F |
S |
G |
E |
R |
V |
R |
Q |
C |
G |
L |
G |
G |
R |
P |
F |
Q |
F |
S |
F |
F |
P |
D |
L |
| Anolis carolinensis | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
T |
G |
Q |
E |
L |
D |
K |
F |
I |
G |
E |
I |
Q |
Y |
G |
L |
F |
Y |
G |
E |
R |
V |
R |
Q |
C |
G |
L |
G |
G |
R |
P |
F |
R |
F |
A |
F |
F |
P |
D |
L |
| Gallus gallus | C |
K |
T |
G |
A |
L |
L |
V |
N |
A |
T |
G |
P |
E |
L |
E |
K |
F |
I |
G |
E |
I |
Q |
Y |
G |
L |
F |
H |
G |
E |
R |
V |
R |
Q |
C |
G |
L |
G |
G |
R |
P |
F |
Q |
F |
S |
F |
F |
P |
D |
L |
| Taeniopygia guttata | C |
S |
T |
G |
A |
L |
L |
V |
N |
A |
S |
G |
P |
E |
L |
H |
K |
F |
I |
G |
H |
I |
Q |
Y |
G |
L |
F |
A |
G |
Q |
R |
V |
R |
Q |
C |
G |
L |
G |
G |
R |
P |
F |
Q |
F |
S |
F |
F |
P |
D |
L |
| Xenopus tropicalis | C |
K |
T |
A |
A |
L |
L |
V |
N |
A |
T |
E |
G |
E |
L |
H |
Q |
F |
V |
G |
E |
I |
Q |
Y |
G |
L |
F |
F |
G |
Q |
R |
V |
K |
Q |
C |
G |
L |
G |
G |
R |
P |
T |
T |
F |
S |
F |
F |
P |
D |
L |
| Danio rerio | C |
Q |
T |
G |
V |
D |
L |
V |
N |
A |
S |
R |
P |
E |
L |
E |
Q |
F |
T |
G |
H |
I |
Y |
Y |
G |
L |
F |
Q |
G |
G |
K |
T |
R |
R |
C |
G |
L |
G |
I |
R |
R |
A |
K |
I |
Y |
I |
F |
P |
K |
L |
| Gasterosteus aculeatus | C |
R |
T |
G |
A |
E |
L |
V |
N |
A |
T |
G |
A |
E |
L |
D |
K |
F |
L |
G |
E |
L |
N |
Y |
G |
L |
F |
H |
G |
Q |
R |
V |
K |
Q |
C |
G |
L |
G |
G |
R |
P |
S |
R |
F |
S |
F |
F |
P |
D |
L |
| Takifugu rubripes | C |
R |
T |
G |
A |
E |
L |
V |
N |
A |
T |
G |
A |
E |
L |
D |
K |
F |
L |
G |
E |
L |
S |
Y |
G |
L |
F |
H |
G |
V |
R |
V |
K |
Q |
C |
G |
L |
G |
G |
R |
A |
S |
R |
F |
S |
F |
F |
S |
E |
L |
| Tetraodon nigroviridis | C |
R |
T |
G |
A |
E |
L |
V |
N |
A |
T |
G |
P |
E |
L |
D |
K |
F |
L |
G |
E |
L |
S |
F |
G |
L |
F |
H |
G |
V |
R |
V |
K |
Q |
C |
G |
L |
G |
G |
R |
P |
R |
R |
F |
S |
F |
F |
P |
E |
L |
Species color legend (basic classification):
Great apes | Other monkeys | Prosimians | Other mammals | Lizards | Birds | Amphibians | Fishes | Insects | Nematods | Tunicates | Echinoderms
Show Venn diagram of alignment
Display WebLogo for the region
Click on the top-left corner to enlarge.
Display alignment phylogenetic tree
Click on the top-left corner to enlarge.
Download tree in Newick format (right-click on the link, and choose 'Save target as').
Display region alignment (21 residues, Fasta format)
Display methods
Ortholog sequences have been selected from the Ensembl(1) and
NCBI websites. Alignment has been performed with
ClustalW(2), version 1.83 or 2.0.7.
Trees have been built using Phylogeny.fr (3), based on the alignments.
Software used is PhyML 3.0 aLRT with default parameters. Pictures of trees have been made using Phylip at Mobyle.
AAPI and AAPIR have been calculated thanks to Bioperl.
WebLogos are drawn with WebLogo 3(14)
Accession numbers
| Secondary structure analysis: |
|
Residu G64 is predicted to belong to a β strand. Probability is 0.925.
Direct environment is as follow:
Observed frequencies in β strands:
G: 0.78
R: 0.86
The two residues are found equivalent in this type of structure.
Display methods
Predictions of secondary structures have been made with PsiPred(9)
, version 2.5, using Protein Multiple Sequences Alignments as input, in order to increase the accuracy of the prediction.
Amino acid frequencies have been calculated from a non redondant set defined by the RCSB. Details are provided
here.
