Printable version Screen version +/- font size on/off fixed menus Accessions & refs Help Slide Show

Ortholog conservation Domain conservation Secondary structure 3D structure More Home

Analysis of p.(Gly25Arg) variant, MYO7A gene, myosin VIIa protein (2215 residues)

• Ortholog conservation:

  
  
  

  Number of sequences	AAPI*	AAPIR**	Number of divergencies	Number of mutant	Number of gaps	Conservation of G25	Conservation - gap
  24	76.99%	74.45%	0 details	0 details	0 details	24 / 24 (100.00%)	24 / 24 (100.00%)

  
  
  

  The alignment does not show any divergent sequences.

  The mutant residue cannot be found in the alignment.

  There is no gap in the alignment.

  *AAPI: Alignment Average Percentage Identity
  **AAPIR: Alignment Average Percentage Identity of the Region (20 residues surrounding position 25). AAPIR appears in green if it is more than 10% compared to AAPI, in red if less than 10%.

  You can check the AAPIRs compared with AAPI of the whole alignment by clicking here. The help page will tell you more.

  Informativity of this alignment: P₀ = 0.0150, with an average substitution per position of 4.20.
  This means that you have a probability of 0.9850 (98.50%) that position 25 is invariant because it is functionally constrained.
  More information here.

  Display alignment

  Click on the alignment to zoom in and out.

  |

  |

  25

  |

  |

  Homo sapiens

  V

  I

  L

  Q

  Q

  G

  D

  H

  V

  W

  M

  D

  L

  R

  L

  G

  Q

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  V

  Q

  V

  V

  D

  D

  E

  D

  N

  E

  H

  W

  I

  S

  P

  Pan troglodytes

  A

  L

  L

  Q

  K

  G

  D

  H

  V

  W

  M

  D

  L

  R

  S

  G

  Q

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  V

  Q

  V

  V

  D

  D

  E

  D

  N

  E

  H

  W

  I

  S

  P

  Macaca mulatta

  A

  L

  L

  Q

  K

  G

  D

  Y

  V

  W

  M

  D

  L

  R

  S

  G

  Q

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Felis catus

  -

  -

  H

  R

  M

  G

  D

  Y

  V

  W

  M

  D

  L

  R

  S

  G

  Q

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Cavia porcellus

  A

  S

  H

  P

  Q

  G

  D

  Y

  V

  W

  M

  D

  L

  R

  S

  G

  Q

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Mus musculus

  V

  I

  L

  Q

  K

  G

  D

  Y

  V

  W

  M

  D

  L

  K

  S

  G

  Q

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  D

  N

  E

  H

  W

  I

  S

  P

  Rattus norvegicus

  V

  I

  L

  Q

  K

  G

  D

  Y

  V

  W

  M

  D

  L

  K

  S

  G

  Q

  E

  -

  F

  D

  V

  P

  I

  G

  A

  M

  V

  K

  L

  C

  E

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Canis familiaris

  -

  -

  M

  D

  S

  G

  D

  Y

  V

  W

  M

  D

  L

  R

  S

  G

  Q

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Bos taurus

  -

  -

  -

  -

  -

  -

  -

  -

  -

  -

  M

  D

  L

  R

  S

  G

  Q

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Equus caballus

  -

  -

  -

  -

  -

  G

  D

  Y

  V

  W

  M

  D

  L

  R

  S

  G

  Q

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Monodelphis domestica

  F

  F

  L

  L

  Q

  G

  D

  Y

  V

  W

  M

  D

  L

  K

  T

  G

  Q

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Anolis carolinensis

  Y

  V

  F

  F

  Q

  G

  D

  Y

  V

  W

  M

  D

  L

  K

  T

  G

  R

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Gallus gallus

  T

  L

  C

  L

  Q

  G

  D

  Y

  V

  W

  M

  D

  L

  K

  T

  G

  R

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Taeniopygia guttata

  C

  L

  W

  F

  Q

  G

  D

  Y

  V

  W

  M

  D

  L

  K

  T

  G

  R

  E

  -

  F

  D

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Tetraodon nigroviridis

  V

  I

  V

  Q

  Q

  G

  D

  Y

  V

  W

  L

  D

  L

  K

  T

  G

  R

  E

  -

  F

  D

  V

  P

  V

  G

  A

  I

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  A

  D

  D

  E

  G

  R

  E

  H

  W

  I

  S

  P

  Danio rerio

  V

  I

  L

  Q

  Q

  G

  D

  Y

  V

  W

  L

  D

  L

  K

  T

  G

  H

  E

  -

  F

  E

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  L

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Oryzias latipes

  S

  T

  F

  V

  Q

  G

  D

  Y

  V

  W

  L

  D

  L

  K

  T

  G

  R

  E

  -

  F

  E

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Takifugu rubripes

  -

  -

  L

  F

  Q

  G

  D

  Y

  V

  W

  L

  D

  L

  K

  S

  G

  R

  E

  -

  F

  E

  V

  P

  I

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  T

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Gasterosteus aculeatus

  Y

  S

  S

  A

  Q

  G

  D

  F

  V

  W

  L

  D

  L

  K

  T

  G

  R

  E

  -

  F

  E

  V

  P

  V

  G

  A

  V

  V

  K

  L

  C

  D

  S

  G

  Q

  I

  Q

  V

  Q

  D

  D

  E

  G

  N

  E

  H

  W

  I

  S

  P

  Aedes aegypti

  -

  -

  -

  -

  M

  G

  D

  Y

  I

  W

  I

  E

  P

  V

  S

  G

  R

  E

  -

  F

  D

  V

  A

  I

  G

  A

  R

  V

  I

  S

  A

  E

  G

  R

  R

  I

  Q

  V

  R

  D

  D

  D

  G

  N

  E

  L

  W

  L

  T

  P

  Drosophila melanogaster

  V

  I

  V

  T

  R

  G

  D

  Y

  I

  W

  I

  E

  P

  A

  S

  G

  R

  E

  -

  F

  D

  V

  A

  I

  G

  A

  R

  V

  V

  S

  A

  E

  G

  R

  R

  I

  Q

  V

  R

  D

  D

  D

  G

  D

  E

  V

  W

  L

  A

  P

  Caenorhabditis elegans

  V

  L

  V

  S

  K

  G

  D

  F

  I

  W

  I

  E

  P

  G

  K

  T

  E

  G

  -

  -

  S

  I

  P

  I

  G

  A

  R

  V

  I

  D

  Q

  D

  H

  G

  R

  L

  K

  V

  I

  D

  D

  L

  G

  N

  E

  Q

  W

  L

  S

  A

  Ciona savignyi

  E

  L

  F

  F

  Q

  G

  D

  H

  I

  W

  L

  L

  D

  K

  A

  T

  Q

  N

  G

  T

  K

  V

  P

  L

  G

  A

  V

  V

  K

  M

  S

  D

  S

  G

  Q

  V

  K

  V

  V

  D

  D

  E

  G

  N

  E

  H

  W

  L

  K

  S

  Ciona intestinalis

  F

  N

  V

  F

  Q

  G

  D

  H

  I

  W

  L

  L

  D

  K

  A

  T

  Q

  N

  G

  T

  K

  V

  P

  L

  G

  A

  V

  V

  K

  M

  S

  D

  S

  G

  Q

  V

  K

  V

  I

  D

  D

  E

  G

  T

  E

  H

  W

  L

  K

  S

  
  

  Species color legend (basic classification):

  Great apes | Other monkeys | Prosimians | Other mammals | Lizards | Birds | Amphibians | Fishes | Insects | Nematods | Tunicates | Echinoderms

  Show Venn diagram of alignment

  Display WebLogo for the region

  Click on the top-left corner to enlarge.

  

  Display alignment phylogenetic tree

  Click on the top-left corner to enlarge.

  
  

  Download tree in Newick format (right-click on the link, and choose 'Save target as').

  Display region alignment (21 residues, Fasta format)

  Display methods

  Ortholog sequences have been selected from the Ensembl⁽¹⁾ and NCBI websites. Alignment has been performed with ClustalW⁽²⁾, version 1.83 or 2.0.7. Trees have been built using Phylogeny.fr ⁽³⁾, based on the alignments. Software used is PhyML 3.0 aLRT with default parameters. Pictures of trees have been made using Phylip at Mobyle. AAPI and AAPIR have been calculated thanks to Bioperl. WebLogos are drawn with WebLogo 3⁽¹⁴⁾

  Accession numbers

• Domain conservation:

  The residue belongs to the domain Motor domain.

  1

  729

  	A >700 residues domain in myosin VIIa, which is able to bind ATP and generates movements along actin filaments.

  
  
  
  
  

  There are no alignments available concerning the domain Motor domain of the protein myosin VIIa or the residue is not present in the alignment.

• Secondary structure analysis:

  Residu G25 is predicted to belong to a loop. Probability is 0.734.

  Direct environment is as follow:

  D	V	P	I	G25	A	V	V	K

  
  
  

  Display methods

  Predictions of secondary structures have been made with PsiPred⁽⁹⁾ , version 2.5, using Protein Multiple Sequences Alignments as input, in order to increase the accuracy of the prediction. Amino acid frequencies have been calculated from a non redondant set defined by the RCSB. Details are provided here.

• 3D analysis:

  No 3D model available at this position.

  Check 3D coverage of myosin VIIa

• Additional ressources:

  
  
  
  • UNIPROT annotations
    

    The variation is not reported in Uniprot.

  • Click on the LOVD picture to check if a variant is described at position 25    
    
    
    
    
  • Graphical display of the region at NCBI (including SNPs)

See accession numbers of sequences used or references.

Execution time: 1 wallclock secs ( 0.07 usr 0.01 sys + 0.75 cusr 0.31 csys = 1.14 CPU)