Ortholog conservation: |
|
Number of sequences |
AAPI* |
AAPIR** |
Number of divergencies |
Number of mutant |
Number of gaps |
Conservation of A366 |
Conservation - gap |
18 |
80.21% |
92.75% |
0 details |
0 details |
1 details |
17 / 18 (94.44%) |
17 / 17 (100.00%) |
The alignment does not show any divergent sequences.
The mutant residue cannot be found in the alignment.
Following species have a gap at the position:
*AAPI: Alignment Average Percentage Identity
**AAPIR: Alignment Average Percentage Identity of the Region (20 residues surrounding position 366). AAPIR appears in green if it is more than 10% compared to AAPI, in red if less than 10%.
You can check the AAPIRs compared with AAPI of the whole alignment by clicking here.
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Display alignment
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| | | | | | | | | | | | | | | | | | | | | | | | | | | 366 | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Homo sapiens | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
V |
D |
K |
D |
E |
N |
L |
G |
L |
N |
S |
M |
F |
E |
V |
Y |
L |
V |
Pan troglodytes | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
V |
D |
K |
D |
E |
- |
- |
G |
L |
N |
S |
M |
F |
E |
V |
Y |
L |
V |
Macaca mulatta | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
V |
D |
K |
D |
E |
D |
W |
G |
L |
N |
S |
M |
F |
E |
V |
Y |
L |
V |
Cavia porcellus | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
V |
D |
K |
D |
E |
- |
- |
G |
L |
N |
S |
M |
F |
E |
V |
Y |
L |
V |
Mus musculus | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
V |
D |
K |
D |
E |
N |
L |
G |
L |
N |
S |
M |
F |
E |
V |
Y |
L |
V |
Rattus norvegicus | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
V |
D |
K |
D |
E |
- |
- |
G |
L |
N |
S |
M |
F |
E |
V |
Y |
L |
V |
Equus caballus | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
V |
D |
K |
D |
E |
- |
- |
G |
L |
N |
S |
M |
F |
E |
V |
Y |
L |
V |
Bos taurus | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
V |
D |
K |
D |
E |
T |
Q |
G |
L |
N |
S |
M |
F |
E |
V |
Y |
L |
V |
Canis familiaris | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
V |
D |
K |
D |
E |
- |
- |
G |
L |
N |
S |
M |
F |
E |
V |
Y |
L |
V |
Felis catus | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
V |
D |
K |
D |
E |
- |
- |
G |
L |
N |
S |
M |
F |
E |
V |
Y |
L |
V |
Monodelphis domestica | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
V |
D |
K |
D |
E |
- |
- |
G |
L |
N |
S |
M |
F |
E |
V |
Y |
L |
V |
Anolis carolinensis | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
P |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
Q |
D |
K |
D |
E |
- |
- |
G |
L |
N |
S |
V |
F |
E |
V |
Y |
L |
V |
Gallus gallus | N |
D |
N |
A |
P |
E |
F |
N |
S |
S |
E |
Y |
S |
V |
A |
I |
P |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
Q |
D |
K |
D |
E |
- |
- |
G |
P |
N |
S |
V |
F |
E |
V |
Y |
L |
V |
Taeniopygia guttata | N |
D |
N |
A |
P |
E |
F |
N |
A |
S |
E |
Y |
S |
V |
A |
I |
P |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
V |
Q |
D |
K |
D |
E |
- |
- |
G |
P |
N |
S |
V |
F |
E |
V |
Y |
L |
V |
Danio rerio | N |
D |
N |
P |
P |
R |
F |
N |
S |
S |
E |
Y |
R |
V |
L |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
Y |
I |
Q |
V |
E |
D |
K |
D |
E |
- |
- |
G |
V |
N |
S |
M |
F |
Q |
V |
F |
L |
T |
Oryzias latipes | - |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
Takifugu rubripes | N |
D |
N |
A |
P |
K |
F |
N |
S |
S |
E |
Y |
R |
V |
R |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
A |
E |
D |
K |
D |
E |
- |
- |
G |
V |
N |
S |
M |
F |
Q |
V |
F |
L |
T |
Gasterosteus aculeatus | N |
D |
N |
A |
P |
T |
F |
N |
S |
S |
E |
Y |
R |
V |
L |
I |
T |
E |
L |
A |
Q |
V |
G |
F |
A |
L |
P |
L |
F |
I |
Q |
A |
E |
D |
K |
D |
E |
- |
- |
G |
V |
N |
S |
M |
F |
Q |
V |
F |
L |
R |
Species color legend (basic classification):
Great apes | Other monkeys | Prosimians | Other mammals | Lizards | Birds | Amphibians | Fishes | Insects | Nematods | Tunicates | Echinoderms
Show Venn diagram of alignment
Display WebLogo for the region
Click on the top-left corner to enlarge.
Display alignment phylogenetic tree
Click on the top-left corner to enlarge.
Download tree in Newick format (right-click on the link, and choose 'Save target as').
Display region alignment (21 residues, Fasta format)
Display methods
Ortholog sequences have been selected from the Ensembl(1) and
NCBI websites. Alignment has been performed with
ClustalW(2), version 1.83 or 2.0.7.
Trees have been built using Phylogeny.fr (3), based on the alignments.
Software used is PhyML 3.0 aLRT with default parameters. Pictures of trees have been made using Phylip at Mobyle.
AAPI and AAPIR have been calculated thanks to Bioperl.
WebLogos are drawn with WebLogo 3(14)
Accession numbers
Domain conservation: |
|
The residue belongs to the domain Cadherin 4.
Cadherin 4 of cadherin 23 domain alignment including p.A366 residue.
Number of sequences |
AAPID*** (from aa 349 to aa 460) |
AAPIR! |
Number of divergencies |
Number of mutant |
Number of gaps |
Conservation of A366 |
Conservation - gap |
1879 |
26.06% |
27.10% |
1599 details |
95 |
222 |
58 / 1879 (3.09%) |
58 / 1657 (3.50%) |
Divergencies
Residues present in more than 10% of the sequences are highlighted in blue.
C - 0.16% |
D - 0.53% |
E - 3.67% |
F - 3.30% |
G - 0.21% |
H - 3.99% |
I - 4.84% |
K - 2.45% |
L - 15.75% |
M - 1.22% |
N - 0.75% |
P - 7.13% |
Q - 1.81% |
R - 6.01% |
S - 10.70% |
T - 5.06% |
V - 15.49% |
W - 0.32% |
Y - 1.70% |
If we just consider Cadherin domain of cadherin 23, we can add that:
on 27 sequences, conservation is 2/27 (7.41%),
or 2/27 (7.41%) if you do not take the gaps into account.
***AAPID: Alignment Average Percentage Identity of the Domain (positions are indicated).
!AAPIR is here compared with AAPID.
Show Venn diagram of alignment
Display WebLogo for the region
Click on the top-left corner to enlarge.
Display complete alignment (Clustal format)
Display region alignment (21 residues, Fasta format)
Display methods